Recent Publications
2024
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2023
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2022
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2021
Thapa P, Upadhyay SP, Suo WZ, Singh V, Gurung P, Lee ES, Sharma R, Sharma M. Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease. Bioorg Chem. 2021 Mar;108:104681. doi: 10.1016/j.bioorg.2021.104681. Epub 2021 Jan 29. PMID: 33571811; PMCID: PMC7928223.
Marques-da-Silva C, Poudel B, Baptista RP, Peissig K, Hancox LS, Shiau JC, Pewe LL, Shears MJ, Kanneganti TD, Sinnis P, Kyle DE, Gurung P, Harty JT, Kurup SP. Altered cleavage of caspase-1 in hepatocytes limits control of Malaria in the liver. BioRxiv. 2021. https://doi.org/10.1101/2021.01.28.427517. Currently submitted to Cell reports.
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2020
Malireddi RKS*, Gurung P*, Kesavardhana S, Samir P, Burton A, Mummareddy H, Vogel P, Pelletier S, Burgula S, Kanneganti TD. Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease. J Exp Med. 2020 Mar 2;217(3). pii: e20191644. doi: 10.1084/jem.20191644. PubMed PMID: 31869420. *Equal first author.
Mazgaeen L, Gurung P. Recent advances in lipopolysaccharide recognition systems. Int J Mol Sci. 2020 Jan 7;21(2). pii: E379. doi: 10.3390/ijms21020379. Review. PubMed PMID: 31936182; PubMed Central PMCID: PMC7013859.
Malireddi RKS*, Gurung P*, Kesavardhana S, Samir P, Burton A, Mummareddy H, Vogel P, Pelletier S, Burgula S, Kanneganti TD. Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease. J Exp Med. 2020 Mar 2;217(3). pii: e20191644. doi: 10.1084/jem.20191644. PubMed PMID: 31869420. *Equal first author.
Mazgaeen L, Gurung P. Recent advances in lipopolysaccharide recognition systems. Int J Mol Sci. 2020 Jan 7;21(2). pii: E379. doi: 10.3390/ijms21020379. Review. PubMed PMID: 31936182; PubMed Central PMCID: PMC7013859.
Dasari TK, Geiger R, Karki R, Banoth B, Sharma BR, Gurung P, Burton A, Kanneganti TD. The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis. J Biol Chem. 2020 Mar 13;295(11):3394-3400. doi: 10.1074/jbc.RA119.010623. Epub 2019 Nov 12. PMID:31719149; PMCID: PMC7076204.
Tartey S, Gurung P, Karki R, Burton A, Hertzog P, Kanneganti TD. Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation. Cell Mol Immunol. 2020 Mar 19. doi: 10.1038/s41423-020-0398-7. Epub ahead of print. PMID: 32203187.
Mazgaeen L, Gurung P. Neutro"feels" lethal toxin. J Leukoc Biol. 2020 May 13. doi: 10.1002/JLB.4CE0320-101R. Epub ahead of print. PMID: 32401416.
Harrington V, Gurung P. Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis. Immunol Rev. 2020 Jun 20. doi: 10.1111/imr.12886. Epub ahead of print. PMID: 32564424.
Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 governs pathogenic T cell responses during Leishmania major infection. Immunohorizons. 2020 Sep 18;4(9):546-560. doi: 10.4049/immunohorizons.2000076. PMID: 32948646.
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2019
Geesala R, Schanz W, Biggs M, Dixit G, Skurski J, Gurung P, Meyerholz DK, Elliott D, Issuree PD, Maretzky T. Loss of RHBDF2 results in an early-onset spontaneous murine colitis. J Leukoc Biol. 2019 Apr;105(4):767-781. doi: 10.1002/JLB.4A0718-283RR. Epub 2019 Jan 29. PubMed PMID: 30694569.
Yorek MS, Poudel B, Mazgaeen L, Pope RM, Wilson ME, Gurung P. Leishmania major degrades murine CXCL1 - An immune evasion strategy. PLoS Negl Trop Dis. 2019 Jul 1;13(7):e0007533. doi: 10.1371/journal.pntd.0007533. eCollection 2019 Jul. PubMed PMID: 31260451; PubMed Central PMCID: PMC6625741.
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2018
Tartey S, Gurung P, Dasari TK, Burton A, Kanneganti TD. ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis. J Clin Invest. 2018 May 1;128(5):2042-2047. doi: 10.1172/JCI98446. Epub 2018 Apr 9. PubMed PMID: 29629899; PubMed Central PMCID: PMC5919885.
Malireddi RKS*, Gurung P*, Mavuluri J, Dasari TK, Klco JM, Chi H, Kanneganti TD.TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation J Exp Med. 2018 Mar 2. pii: jem.20171922. doi: 10.1084/jem.20171922. PMID: 29500178 *Equal contribution (Read the Insights in JEM and press release on this article).
Poudel B, Gurung P. An update on cell intrinsic negative regulators of the NLRP3 inflammasome. J Leukoc Biol. 2018 Jan 26. doi: 10.1002/JLB.3MIR0917-350R. [Epub ahead of print] Review. PubMed PMID: 29377242 *Manuscript selected for Cover Image in JLB June 2018 Issue.
Sharma BR, Karki R, Lee E, Zhu Q, Gurung P, Kanneganti TD. Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice. Cell Death Differ. 2018 Jul 23. doi: 10.1038/s41418-018-0159-7. [Epub ahead of print] PubMed PMID: 30038386.
Tartey S, Gurung P, Samir P, Burton A, Kanneganti TD. Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses. J Immunol. 2018 Aug 6. pii: ji1800760. doi: 10.4049/jimmunol.1800760. [Epub ahead of print] PubMed PMID: 30082320.
Poudel B, Gurung P. Allergic asthma: RIPK2 takes the lead. J Leukoc Biol. 2018 Sep;104(3):441-443. doi: 10.1002/JLB.3CE0718-293. Epub 2018 Aug 14. PubMed PMID: 30106490.
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2017
Gurung P, Fan G, Lukens JR, Vogel P, Tonks NK, Kanneganti TD. Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease. Immunity. 2017 Apr 18;46(4):635-648. doi: 10.1016/j.immuni.2017.03.014. Epub 2017 Apr 11.
PMID: 28410990 (Read the Highlight in Cellular & Molecular Immunology)
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2016
Gurung P, Sharma BR, Kanneganti TD. Distinct role of IL-1β in instigating disease in Sharpin(cpdm) mice. Sci Rep. 2016 Nov 28;6:36634. doi: 10.1038/srep36634.
PMID: 27892465
Qi X, Man SM, Malireddi RK, Karki R, Lupfer C, Gurung P, Neale G, Guy CS, Lamkanfi M, Kanneganti TD. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med. 2016 Sep 19;213(10):2081-97. doi: 10.1084/jem.20151938. Epub 2016 Aug 22.
PMID: 27551156
Gurung P, Kanneganti TD. Autoinflammatory Skin Disorders: The Inflammasomme in Focus. Trends Mol Med. 2016 Jul;22(7):545-64. doi: 10.1016/j.molmed.2016.05.003. Epub 2016 Jun 3. Review.
PMID: 27267764
Phillips FC, Gurung P, Kanneganti TD. Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease. Gut Microbes. 2016 Jul 3;7(4):334-341. Epub 2016 May
PMID: 27148834
Gurung P, Burton A, Kanneganti TD. NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4452-7. doi: 10.1073/pnas.1601636113. Epub 2016 Apr 6.
PMID: 27071119
Gurung P, Kanneganti TD. Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors. Cell Mol Life Sci. 2016 Aug;73(16):3035-51. doi: 10.1007/s00018-016-2212-3. Epub 2016 Mar 31. Review.
PMID: 27032699
Qi X, Gurung P, Malireddi RK, Karmaus PW, Sharma D, Vogel P, Chi H, Green DR, Kanneganti TD. Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol. 2017 Jan;10(1):128-138. doi: 10.1038/mi.2016.25. Epub 2016 Mar 23.
PMID: 270076764
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2015
Gurung P, Li B, Subbarao Malireddi RK, Lamkanfi M, Geiger TL, Kanneganti TD. Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation. Sci Rep. 2015 Sep 28;5:14488. doi: 10.1038/srep14488.
PMID: 26412089
Gurung P, Kanneganti TD. NLRP12 in autoimmune diseases. Oncotarget. 2015 Aug 21;6(24):19950-1. No abstract available.
PMID: 26343520
Gurung P, Kanneganti TD. Innate immunity against Leishmania infections. Cell Microbiol. 2015 Sep;17(9):1286-94. doi: 10.1111/cmi.12484. Epub 2015 Aug 11. Review.
PMID: 26249747
Man SM, Zhu Q, Zhu L, Liu Z, Karki R, Malik A, Sharma D, Li L, Malireddi RK, Gurung P, Neale G, Olsen SR, Carter RA, McGoldrick DJ, Wu G, Finkelstein D, Vogel P, Gilbertson RJ, Kanneganti TD. Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. Cell. 2015 Jul 2;162(1):45-58. doi: 10.1016/j.cell.2015.06.001. Epub 2015 Jun 18. PubMed [citation]
PMID: 26095253
Gurung P, Man SM, Kanneganti TD. A20 is a regulator of necroptosis. Nat Immunol. 2015 Jun;16(6):596-7. doi: 10.1038/ni.3174.
PMID: 25988900
Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, et al. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat Genet. 2015 Jun;47(6):607 14. doi: 10.1038/ng.3283. Epub 2015 May 4.
PMID: 25938942
Lukens JR, Gurung P, Shaw PJ, Barr MJ, Zaki MH, Brown SA, Vogel P, Chi H, Kanneganti TD. The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by
Modulating Interleukin-4 Production in T Cells. Immunity. 2015 Apr 21;42(4):654-64. doi: 10.1016/j.immuni.2015.03.006. Epub 2015 Apr 14.
PMID: 25888258
