Welcome to the Gurung lab

In the Gurung Lab, we study how pattern recognition receptors (PRR) are involved in sensing pathogen- and host-derived molecular patterns to induce inflammation and maintain homeostasis. 

Research Projects

PRRs sense pathogen/damage-associated molecular patterns to protect and maintain cellular homeostasis. Nod like receptors (NLRs), a family of cytoplasmic sensors, recognize pathogen/damage-associated molecules within the cell. Several studies including ours have shown that these NLRs play a central role, not only in viral, bacterial and parasitic infections but also in autoinflammatory and autoimmune diseases. The research goals of our lab are to investigate how these NLRs regulate innate and adaptive immune responses. 



Lab News

Gurung Lab received an EHSRC pilot grant. Read the full story here. https://internalmedicineiowa.org/2018/04/23/gurung-to-examine-generation...

A collaborative work with the Kanneganti Lab on the role of ASK1/2 in autoinflammatory skin disease was recently published in JCI. https://www.jci.org/articles/view/98446

Prajwal was highlighted in the Internal Medicine Rounds. Read the full story here. https://internalmedicineiowa.org/2018/03/22/gurung-wins-travel-grant-and...

Barun's PhD work has been published in Scientific reports. https://www.nature.com/articles/s41598-018-23240-6.pdf 

Our work on the role of TAK1 in regulating NLRP3 inflammasome is published in JEM and online now. Check out the link for the full manuscript. http://jem.rupress.org/content/early/2018/03/01/jem.20171922.

Review on negative regulation of the NLRP3 inflammasome is online now. Check out the link for our review manuscript. http://onlinelibrary.wiley.com/doi/10.1002/JLB.3MIR0917-350R/full

Matt Yorek joined the lab in December 2017. 

Prajwal was awarded the NIH K22 grant to study the role of IL-1alpha in autoinflammatory diseases. Please check the link for full details. https://internalmedicineiowa.org/2018/01/08/gurung-awarded-k22-in-inflam...

August 25, 2017: Prajwal was invited to give a talk at the 24th Annual MMPC Meeting in August. The complete program can be found at this link. https://biology.nd.edu/conferences/2017-midwest-microbial-pathogenesis-c...

July 24, 2017: Nitya Virrippil joins Gurung lab. 

June 26, 2017: Barun Paudel, Ph.D. joins Gurung lab

June 19, 2017: Mike Wurth joins Gurung lab

June 1, 2017:  Dalip Saini joins Gurung lab.

April 18, 2017:  "Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein" study published 

April 17, 2017: Gurung Lab is officially open for business.